Sputum induction with inhaled mannitol in children.
نویسندگان
چکیده
Mannitol is used as an indirect challenge test to assess airway hyperresponsiveness in asthmatic adults and children as young as 4 years old [1–4]. Recently, it has been tested with success in adults as a sputum inducer [5, 6]. In children, induced sputum is usually obtained by hypertonic saline solution (HSS) and has several indications, such as sample obtaining in infectious diseases [7], monitoring severe asthma [8] and defining asthma phenotypes [9].
منابع مشابه
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References 1 Koskela HO, Hyvärinen L, Brannan JD, et al. Responsiveness to three bronchial provocation tests in patients with asthma. Chest 2003; 124: 2171–2177. 2 Brannan JD, Anderson SD, Perry CP, et al. The safety and efficacy of inhaled dry powder mannitol as a bronchial provocation test for airway hyperresponsiveness: a phase 3 comparison study with hypertonic (4.5%) saline. Respir Res 200...
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INTRODUCTION Inhaled mannitol has beneficial effects on lung function, mucociliary clearance, quality of life and sputum properties. This trial examined the efficacy of inhaled mannitol in children with cystic fibrosis (CF). METHODS The efficacy of inhaled mannitol in children with CF aged 6-17years was assessed in a phase 2, randomised, placebo-controlled crossover study. Subjects were rando...
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BACKGROUND Osmotic agents, such as inhaled dry powder mannitol, may increase mucociliary clearance by rehydrating the airway surface liquid and thus act as disease-modifying treatments in cystic fibrosis (CF). This is the first therapeutic trial of inhaled mannitol in children with CF; it was compared with recombinant human deoxyribonuclease (rhDNase), the current best established mucolytic tre...
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ورودعنوان ژورنال:
- The European respiratory journal
دوره 46 2 شماره
صفحات -
تاریخ انتشار 2015